Adi Laurentiu Tarca

Professor Center for Molecular Medicine and Genetics (primary) & Department of Obstetrics and Gynecology (joint), Wayne State University, School of Medicine.

Adjunct Professor Department of Computer Science, Wayne State University, College of Engineering.

 

Education

• 11/2003 – 07/2005 Postdoctoral Fellowship in Bioinformatics, Forest Biology Research Center and the CHUL Research Center, Laval University, Quebec, Canada
• 01/2001 – 10/2003 Ph.D. in Chemical Engineering, Laval University, Quebec, Canada, Thesis: Neural Networks in Multiphase Reactors Data Mining: Feature Selection, Prior Knowledge, and Model Design.
• 09/1999 – 06/2000 M.Sc. in Electrochemistry National Polytechnic Institute of Grenoble, Grenoble, France, Thesis: Modeling the Kinetic Behavior of Electrochemical Reactions.
• 10/1994 – 07/1999 B.Sc. In Chemical Engineering, Polytechnic University of Bucharest, Romania.

 

Research interests

• High-throughput data analysis including, differential expression, alternative splicing
• next generation sequencing data analysis
• outcome prediction using machine learning methods
• gene set and pathway analysis
• longitudinal data analysis

For a list of publications of please see click here.

A few publications by Adi L. Tarca and co-authors are listed below:

 

• Tarca AL, Romero R, Pique-Regi R, Pacora P, Done B, Kacerovsky M, et al. Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy. BMC Med Genomics. 2020;13(1):25. doi: 10.1186/s12920-020-0690-5.

   

• Tarca AL, Romero R, Erez O, Gudicha DW, Than NG, Benshalom-Tirosh N, et al. Maternal whole blood mRNA signatures identify women at risk of early preeclampsia: a longitudinal study. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2020:1-12. doi: 10.1080/14767058.2019.1685964.

   

• Pique-Regi R, Romero R, Tarca AL, Luca F, Xu Y, Alazizi A, et al. Does the human placenta express the canonical cell entry mediators for SARS-CoV-2? Elife. 2020;9. doi: 10.7554/eLife.58716.

   

• Para R, Romero R, Gomez-Lopez N, Tarca AL, Panaitescu B, Done B, et al. Maternal circulating concentrations of soluble Fas and Elabela in early- and late-onset preeclampsia. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2020:1-14. doi: 10.1080/14767058.2020.1716720.

   

• • Gomez-Lopez N, Arenas-Hernandez M, Romero R, Miller D, Garcia-Flores V, Leng Y, et al. Regulatory T Cells Play a Role in a Subset of Idiopathic Preterm Labor/Birth and Adverse Neonatal Outcomes. Cell Rep. 2020;32(1):107874. doi: 10.1016/j.celrep.2020.107874.

 

• • Bhatti G, Romero R, Rice GE, Fitzgerald W, Pacora P, Gomez-Lopez N, et al. Compartmentalized profiling of amniotic fluid cytokines in women with preterm labor. PloS one. 2020;15(1):e0227881. doi: 10.1371/journal.pone.0227881.

 

• • Bhatti G, Romero R, Cherukuri K, Gudicha DW, Yeo L, Kavdia M, et al. Fetal growth percentile software: a tool to calculate estimated fetal weight percentiles for 6 standards. American journal of obstetrics and gynecology. 2020;222(6):625-8. doi: 10.1016/j.ajog.2020.02.006.

 

• • Tarca AL, Romero R, Xu Z, Gomez-Lopez N, Erez O, Hsu CD, et al. Targeted expression profiling by RNA-Seq improves detection of cellular dynamics during pregnancy and identifies a role for T cells in term parturition. Scientific reports. 2019;9(1):848. doi: 10.1038/s41598-018-36649-w.

 

• • Tarca AL, Romero R, Benshalom-Tirosh N, Than NG, Gudicha DW, Done B, et al. The prediction of early preeclampsia: Results from a longitudinal proteomics study. PloS one. 2019;14(6):e0217273. doi: 10.1371/journal.pone.0217273.

 

• • Slutsky R, Romero R, Xu Y, Galaz J, Miller D, Done B, et al. Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor. J Immunol Res. 2019;2019:3128010. doi: 10.1155/2019/3128010.

 

• • Pique-Regi R, Romero R, Tarca AL, Sendler ED, Xu Y, Garcia-Flores V, et al. Single cell transcriptional signatures of the human placenta in term and preterm parturition. Elife. 2019;8. doi: 10.7554/eLife.52004.

 

• • Peiris HN, Romero R, Vaswani K, Reed S, Gomez-Lopez N, Tarca AL, et al. Preterm labor is characterized by a high abundance of amniotic fluid prostaglandins in patients with intra-amniotic infection or sterile intra-amniotic inflammation. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2019:1-16. doi: 10.1080/14767058.2019.1702953.

 

• • Kabiri D, Romero R, Gudicha DW, Hernandez-Andrade E, Pacora P, Benshalom-Tirosh N, et al. Prediction of adverse perinatal outcomes by fetal biometry: a comparison of customized and population-based standards. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2019. doi: 10.1002/uog.20299.

 

• • Handelman SK, Romero R, Tarca AL, Pacora P, Ingram B, Maymon E, et al. The plasma metabolome of women in early pregnancy differs from that of non-pregnant women. PloS one. 2019;14(11):e0224682. doi: 10.1371/journal.pone.0224682.

 

• • Gomez-Lopez N, Romero R, Tarca AL, Miller D, Panaitescu B, Schwenkel G, et al. Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection. American journal of reproductive immunology. 2019:e13184. doi: 10.1111/aji.13184.

 

• • Gomez-Lopez N, Romero R, Panaitescu B, Miller D, Zou C, Gudicha DW, et al. Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2019:1-11. doi: 10.1080/14767058.2019.1610740.

 

• • Gomez-Lopez N, Romero R, Hassan SS, Bhatti G, Berry SM, Kusanovic JP, et al. The Cellular Transcriptome in the Maternal Circulation During Normal Pregnancy: A Longitudinal Study. Frontiers in immunology. 2019;10:2863. doi: 10.3389/fimmu.2019.02863.

 

• • Balogh A, Toth E, Romero R, Parej K, Csala D, Szenasi NL, et al. Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune Response. Frontiers in immunology. 2019;10:1240. doi: 10.3389/fimmu.2019.01240.

 

• • Arenas-Hernandez M, Romero R, Xu Y, Panaitescu B, Garcia-Flores V, Miller D, et al. Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone. Journal of immunology. 2019;202(9):2585-608. doi: 10.4049/jimmunol.1801350.

 

• • Than NG, Romero R, Tarca AL, Kekesi KA, Xu Y, Xu Z, et al. Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia. Frontiers in immunology. 2018;9:1661. Epub 2018/08/24. doi: 10.3389/fimmu.2018.01661.

 

• • Tarca AL, Romero R, Gudicha DW, Erez O, Hernandez-Andrade E, Yeo L, et al. A new customized fetal growth standard for African American women: the PRB/NICHD Detroit study. American journal of obstetrics and gynecology. 2018;218(2S):S679-S91 e4. Epub 2018/02/10. doi: 10.1016/j.ajog.2017.12.229.

 

• • Tarca AL, Gong X, Romero R, Yang W, Duan Z, Yang H, et al. Human blood gene signature as a marker for smoking exposure: computational approaches of the top ranked teams in the sbv IMPROVER Systems Toxicology challenge. Comput Toxicol. 2018;5:31-7. doi: 10.1016/j.comtox.2017.07.003.

 

• • Sarac OS, Kumar R, Dhanda SK, Balci AT, Bilgen I, Romero R, et al. Species translatable blood gene signature as a marker of exposure to smoking: computational approaches of the top ranked teams in the sbv IMPROVER Systems Toxicology challenge. Comput Toxicol. 2018;5:25-30. Epub 2018/03/21. doi: 10.1016/j.comtox.2017.04.001.

 

• • Gomez-Lopez N, Romero R, Panaitescu B, Leng Y, Xu Y, Tarca AL, et al. Inflammasome activation during spontaneous preterm labor with intra-amniotic infection or sterile intra-amniotic inflammation. American journal of reproductive immunology. 2018;80(5):e13049. Epub 2018/09/19. doi: 10.1111/aji.13049.

 

• • Gomez-Lopez N, Romero R, Maymon E, Kusanovic JP, Panaitescu B, Miller D, et al. Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation. Journal of perinatal medicine. 2018. Epub 2018/11/10. doi: 10.1515/jpm-2018-0271.

 

• • Docheva N, Romero R, Chaemsaithong P, Tarca AL, Bhatti G, Pacora P, et al. The profiles of soluble adhesion molecules in the “great obstetrical syndromes”. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2018:1-24. Epub 2018/01/13. doi: 10.1080/14767058.2018.1427058.

 

• • Belcastro V, Poussin C, Xiang Y, Giordano M, Tripathi KP, Boda A, et al. The sbv IMPROVER Systems Toxicology Computational Challenge: Identification of Human and Species-Independent Blood Response Markers as Predictors of Smoking Exposure and Cessation Status. Comput Toxicol. 2018;5:38-51. doi: 10.1016/j.comtox.2017.07.004.

 

• • Tarca AL, Fitzgerald W, Chaemsaithong P, Xu Z, Hassan SS, Grivel JC, et al. The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery. American journal of reproductive immunology. 2017. Epub 2017/06/07. doi: 10.1111/aji.12686.

 

• • Separovic D, Shields AF, Philip PA, Bielawski J, Bielawska A, Pierce JS, et al. Altered Levels of Serum Ceramide, Sphingosine and Sphingomyelin Are Associated with Colorectal Cancer: A Retrospective Pilot Study. Anticancer research. 2017;37(3):1213-8. Epub 2017/03/21. doi: 10.21873/anticanres.11436.

 

• • Romero R, Erez O, Maymon E, Chaemsaithong P, Xu Z, Pacora P, et al. The maternal plasma proteome changes as a function of gestational age in normal pregnancy: a longitudinal study. American journal of obstetrics and gynecology. 2017;217(1):67 e1- e21. Epub 2017/03/07. doi: 10.1016/j.ajog.2017.02.037.

 

• • Romero R, Chaemsaithong P, Tarca AL, Korzeniewski SJ, Maymon E, Pacora P, et al. Maternal plasma-soluble ST2 concentrations are elevated prior to the development of early and late onset preeclampsia – a longitudinal study. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2017:1-15. Epub 2017/01/25. doi: 10.1080/14767058.2017.1286319.

 

• • Pacora P, Romero R, Erez O, Maymon E, Panaitescu B, Kusanovic JP, et al. The diagnostic performance of the beta-glucan assay in the detection of intra-amniotic infection with Candida species. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2017:1-18. Epub 2017/12/12. doi: 10.1080/14767058.2017.1416083.

 

• • Hernandez-Andrade E, Maymon E, Erez O, Saker H, Luewan S, Garcia M, et al. A Low Cerebroplacental Ratio at 20-24 Weeks of Gestation Can Predict Reduced Fetal Size Later in Pregnancy or at Birth. Fetal diagnosis and therapy. 2017. Epub 2017/09/20. doi: 10.1159/000479684.

 

• • Gomez-Lopez N, Romero R, Xu Y, Plazyo O, Unkel R, Leng Y, et al. A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis. Reproductive sciences. 2017:1933719116687656. Epub 2017/01/27. doi: 10.1177/1933719116687656.

 

• • Erez O, Romero R, Maymon E, Chaemsaithong P, Done B, Pacora P, et al. The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study. PloS one. 2017;12(7):e0181468. Epub 2017/07/25. doi: 10.1371/journal.pone.0181468.

 

• • El-Azzamy H, Balogh A, Romero R, Xu Y, LaJeunesse C, Plazyo O, et al. Characteristic Changes in Decidual Gene Expression Signature in Spontaneous Term Parturition. Journal of pathology and translational medicine. 2017;51(3):264-83. Epub 2017/02/23. doi: 10.4132/jptm.2016.12.20.

 

• • Chaiworapongsa T, Romero R, Erez O, Tarca AL, Conde-Agudelo A, Chaemsaithong P, et al. The prediction of fetal death with a simple maternal blood test at 20-24 weeks: a role for angiogenic index-1 (PlGF/sVEGFR-1 ratio). American journal of obstetrics and gynecology. 2017;217(6):682 e1- e13. Epub 2017/10/19. doi: 10.1016/j.ajog.2017.10.001.

 

• • Xu Y, Romero R, Miller D, Kadam L, Mial TN, Plazyo O, et al. An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment. Journal of immunology. 2016;196(6):2476-91. Epub 2016/02/19. doi: 10.4049/jimmunol.1502055.

 

• • Tarca AL, Hernandez-Andrade E, Ahn H, Garcia M, Xu Z, Korzeniewski SJ, et al. Single and Serial Fetal Biometry to Detect Preterm and Term Small- and Large-for-Gestational-Age Neonates: A Longitudinal Cohort Study. PloS one. 2016;11(11):e0164161. Epub 2016/11/02. doi: 10.1371/journal.pone.0164161.

 

Publications